Objective To localize epileptogenic zone and to analyze its network coherence using high frequency intracranial EEG during seizure.Methods First, a normalized high frequency energy index (HFEI) was calculated using intracranial EEG.Then, the index was used to quantify the epileptogenicity of each electrode.Finally, the wavelet coherence was estimated between epileptogenic and non-epileptogenic electrodes.Results The HFEI of intracranial EEG (1252 contacts) from 8 patients with good postoperative outcome were extracted and those electrodes with HFEI above the threshold were identified as epileptogenic electrodes.Compared with physician’s localization results, the sensitivity of our method was 29.57%, and specificity was 96.67%.Average coherence between epileptic electrodes of the 8 patients selected by HFEI was significantly higher than that between non epileptic electrodes.Conclusions As a nonparametric statistical method, the HFEI index we propose is successfully used to localize epileptogenic network, with higher specificity than previous studies, which meets the need of identifying the key epileptic electrodes during pre-surgical planning.