Objective To select the sterilization mode of disposable radiofrequency plasma electrode,and to verify the sterilization effect. Methods We compared the characteristics and environment of the four commonly used sterilization methods,and chose ethylene oxide sterilization method based on the materials and characteristics of disposable radiofrequency plasma surgical electrodes. After sterilization,the performance of the disposable radiofrequency plasma electrode was confirmed,and biological indicators were used to test the products,microorganisms and ethylene oxide residues. Results We used ethylene oxide sterilization method to sterilize the disposable radiofrequency plasma surgical electrode,the sterilization parameters were determined as follows:pre vacuum 60kPa±5kPa,sterilization temperature 50℃±5℃， relative humidity 55%RH + 20%RH,sterilization pressure 0-5kPa,the holding time 1min,the dosing rate <895g,the sterilizing agent time 6h,the residual vacuum degree -60kPa±5kPa,the number of times of residue removal 3 times,the time of each row 30min,the desorption time of toxic gas14d. Conclusion Ethylene oxide sterilization is a feasible and effective sterilization method for disposable radiofrequency plasma electrode after packaging.