Objective  In order to improve the subjective quality of the stitched panoramic image taken in the operation room, a multi-view image mosaic algorithm based on improved scale invariant feature transform (SIFT) is proposed.Methods An algorithm with local weighted fusion was proposed to eliminate splicing ghosting phenomenon . Moreover, to eliminate stitching crease phenomenon in stitched images, new constraints were proposed and applied in vertical image space transformation to select the accurate matching feature points. Results The proposed algorithm solved the problem of mosaic in the stitched images, for example, the quilting appeared at the sleeve of the surgical gown, the operation shears, the gloves and uneven treatment towel position. Conclusion Better subjective quality of the stitched panoramic operation images is achieved by using the improved algorithm.