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立体定向电极规划中的神经纤维束示踪

Neural fiber tracking in the planning of stereotactic electrode

作者: 张文东  翟方文  丁辉王  广志 
单位:清华大学医学院生物医学工程系(北京100084)
关键词: 弥散张量成像;立体定向电极规划;电极触点;纤维束可视化;3D  Slicer 
分类号:R318.04
出版年·卷·期(页码):2017·36·6(551-557)
摘要:

目的 基于患者的弥散张量成像数据(diffusion tensor imaging,DTI),在立体定向电极手术置入规划过程中提供电极触点周围神经纤维束信息,以帮助医生在更全面掌握脑解剖结构和神经连接情况的基础上制定电极植入规划方案。方法 基于3D Slicer的软件框架和模块化的设计思想,设计了一个可用于计算和呈现电极周围神经束的处理模块。在模块中根据手动规划的立体定向电极路径计算各触点位置的空间坐标,并呈现电极规划方案中电极触点周围的神经纤维束分布情况。结果 在T1加权像上手动选择电极路径后,模块可在影像结构上呈现多支电极路径周围神经纤维束的空间分布和连接情况;并依据电极路径在二维影像上的投影位置及斜切面模式下的显示结果,呈现电极与神经纤维束和影像结构之间的相对位置关系。结论 本文的处理模块可在结构像基础上进一步提供手动选择路径中电极周围纤维束的空间位置及分布范围的信息,辅助医生规划与调整电极置入路径。

Objective Based on patients’ diffusion tensor imaging(DTI),in the processing of planning stereotactic electrode insertion path,the information about neural fiber tracts surrounding the electrode contacts were presented to assist doctors to make plans for electrode insertion based on comprehensively grasping the knowledge about anatomic structure and neural connections in patients’ brain.Methods Based on the framework of 3D Slicer and idea of module design,we developed a scripted module in calculating and displaying fiber tracts around electrodes.The module could calculate contacts’ coordinates according to the manual planning of stereotactic electrode paths and present the distribution of fiber tracts around electrodes’ contacts in the planning scheme.Results After manually selected the electrode insertion paths in T1-weighted images,the distributions and connections of the neural fibers corresponding to the multiple electrode paths in the planning were revealed.According to paths’ projections in 2D slices and displaying in the pattern of the oblique plane,the relative positions of electrodes and their corresponding neural fibers were shown through the module.Conclusions On the basis of structure images,the module in this article could further provide information about the fibers’ positions and distributions around the contacts of electrodes in the manually planning,and assist doctors to plan and adjust the insertion paths of electrodes.

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