Objective A rational usage of the hospital emergency resources can make hospitals fulfill their missions better in emergency rescues. SIMIO model has fast and sensitive simulation capabilities to be used in the discussion of hospital emergency resource allocation. Methods With the investigation of emergency process and emergency resources in a local hospital, a simulation model based on SIMIO is established.According to a registered wounded number in the earthquake of a hospital from literature, several different hospital emergency scenarios are simulated. Results The simulation experiment is carried out to reduce the patients waiting time and to rationalize the resource working time in different emergency scenes. Conclusions This model can be used to quantitatively analyze the emergency resource allocation in hospitals under different emergency scenes. The analysis results can allow the hospital to obtain more data support when formulating relevant emergency plans.