北京生物医学工程

肿瘤热疗无损测温方法的研究进展

Advances in non-invasive temperature measurement methods for hyperthermia

作者：嵇敏洁印佳杨悦韩佳薇吴小玲

单位：南京医科大学生物医学工程与信息学院（南京 211166）

关键词：肿瘤热疗；温度敏感性；无损测温；精确性；热剂量

分类号：R318.04

出版年·卷·期（页码）：2019·38·1（96-101）

摘要：

肿瘤热疗(hyperthermia)是利用肿瘤组织对温度敏感性高于正常组织的性质，即人体正常细胞在42.5~43℃下不会受到损伤，但大部分肿瘤细胞在该温度下会被诱导进入凋亡过程。临床上应用超声、微波或红外等作为加热源，加热并杀死肿瘤组织而使得正常组织基本不受损伤。但是对于如何精确测量肿瘤热疗的温度从而控制热疗剂量仍然是一个难题。本文综述了目前肿瘤热疗过程中电阻抗断层成像（ectrical impedance tomograph，EIT）测温、红外热图引导技术、微波辐射测温法、超声无损测温、磁共振成像测温（magnetic resonance imaging，MRI）等无损测温方法及其研究现状，展望了如何有效精确测量肿瘤热疗时的温度，为控制肿瘤热疗的热剂量提供参考，以期在不伤害正常组织的前提下，使肿瘤组织产生不可逆的损伤。

Hyperthermia is the use of tumor tissue that is more sensitive to temperature than normal tissues . Human normal cells can tolerate 42-43°C for long periods of time without damage, while most tumor cells will be induced into the apoptotic process at 42°C. Ultrasound, microwave or infrared is used as the heating source in clinical practice to heat and kill tumor tissue, so that normal tissue was not damaged. However, it is still difficult to accurately measure the temperature of tumor hyperthermia and control the dose of hyperthermia. This article reviews the methods and research status of non-invasive temperature measurement in tumor hyperthermia, such as electrical impedance tomography (EIT) temperature measurement, infrared thermal image, microwave radiation temperature measurement, ultrasonic non-destructive temperature measurement, magnetic resonance imaging (MRI), etc, forecasts how the temperature measurement method can effectively and accurately measure the temperature during hyperthermia, and provide reference for controlling the thermal dose of tumor hyperthermia, so as to cause irreversible damage to tumor tissue without harming normal tissues.

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