北京生物医学工程

α-CSH / NC 复合植骨材料的理化性质研究

Study on the physicochemical properties of α-CSH/NC composite bone graft

作者：刘金龙刘相成张阿丽迟志永

单位：第80集团军医院（山东潍坊 261042）哈尔滨医科大学附属第一医院（哈尔滨 150001）

关键词： α-硫酸钙；纳米纤维素；植骨材料；理化性质

分类号：R318.08

出版年·卷·期（页码）：2019·38·3（298-302）

摘要：

目的利用纳米纤维素（nanocellulose，NC）的材料特性，增强α-硫酸钙（α-calcium sulphate hemihydrate,α-CSH）的结构稳定性，以获取理化性质更加优异的复合植骨材料。方法以α-CSH为基质，按照NC在复合材料中所占比例0%、1%、2%、3%、4%、5%、7.5%、10%（质量分数）分别制作复合植骨材料，测定其力学强度、密度、代谢速率等理化性能，并行XRD分析以及扫描电镜观察。结果NC能够显著增强α-CSH的力学性能，使其抗压强度达34.87 MPa±2.08MPa，并且使植骨材料密度降低，代谢时间延长。XRD分析示制备过程中无其他物质产生，对其转化产物分析示NC对α-CSH的转化过程无影响。扫描电镜观察可见NC穿梭于晶体空隙之间，形成三维网络结构，并同晶体结构牢固结合。结论NC能够显著增强α-CSH的理化性质，使其更加复合临床植骨需求。

Objective Addition of the nanocellulose (NC) can reinforce the structural stability of α-calcium sulphate hemihydrate (α-CSH), thereby improving the physicochemical properties of composite materials for bone grafts. Methods The bone grafts were fabricated according to the content of NC (0%, 1%, 2%, 3%, 4%, 5%, 7.5% and 10 wt%, respectively) in the α-CSH matrix, and physicochemical properties such as the mechanical strength, density and metabolic rate were tested. In addition, X-ray diffraction (XRD) spectroscopy and scanning electron microscopy (SEM) were used for further characterizations. Results It was found that NC had noticeably improved the mechanical properties of α-CSH (the compressive strength was up to 34.87 MPa±2.08 MPa), reduced the density of bone grafts, and extend the metabolic time. The XRD results showed no new phases formed during the fabrication process, which meant NC showed no effect on the α-CSH transformation process. From the SEM results, NC travelled in the vacancies in the crystal and formed solid three dimensional network structure. Conclusions NC can significantly strengthen the physicochemical properties of α-CSH, which better meets the demand for clinical bone grafting.

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