北京生物医学工程

基于冠状动脉血管分支流量分配方法的血流储备分数数值模拟研究

Numerical simulation of fractional flow reserve based on coronary artery branch flow distribution method

作者：夏骏乔爱科杨青青侯阳马跃

单位：北京工业大学生命科学与生物工程学院（北京 100124）中国医科大学附属第二临床医院（沈阳 110001）

关键词：冠状动脉狭窄；血流储备分数；数值模拟；标度律；血流量分配

分类号：R318.04

出版年·卷·期（页码）：2019·38·3（251-256）

摘要：

目的在个性化无创计算血流储备分数（fractional flow reverse,FFRCT）中，流量边界条件的分配准确性往往是一个问题。本文基于种内标度律，提出了一种体积-流量关系的冠脉血流量分配方法进行血流量分配。方法对16例患者血管造影（CT angiography，CTA）图像进行重建，测量出患者各分支的体积，再经过标度律的方法将冠脉总流量以体积分配比分配到各分支出口。以临床FFR值和最终计算的血流动力学模拟值作分类对比，比较了以往的管径流量模型分配方法和体积流量分配方法的准确性。结果基于体积法计算的FFRCT误差为10.47%，基于管径法计算的FFRCT为11.76%，并且体积分配方法与管径分配方法具有较好的一致性（80%）。结论本文结果可为临床无创检测FFR提出新的计算方法并推动FFRCT的临床应用研究。

objective For the personalized non-invasive calculation offractional flow reverse(FFRCT), the accuracy of the distribution of flow boundary conditions is a key issue. According to the intra-species scaling law, we propose a volume-flow relationship based coronary blood flow distribution method for blood flow in coronary branches. Methods The CT angiography (CTA) images of 16 patients were reconstructed, and the volume of each branch of the patient was measured. The total volume of the coronary artery was distributed to each branch outlet by volumetric ratio. The clinical FFR values and the final calculated hemodynamic simulation values were compared, and the accuracy of the commonly used diameter flow model and volume flow distribution method was compared. Results The FFFCT error calculated by the volume method and by the diameter method was 10.47% and 11.76% respectively, and the volume distribution method had the same consistency (80%) with the diameter distribution method. Conclusions This work may provide a new calculation method for clinical non-invasive detection FFR and promote the clinical application of FFRCT.

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