北京生物医学工程

不同材质斑块的狭窄颈动脉模型中新型锌合金支架的支撑性能研究

Support performance of new type zinc alloy stent in stenotic carotid arteries model with different materials plaques

作者：李子豪乔爱科王斯睿崔新阳

单位：北京工业大学生命科学与生物工程学院 ( 北京 100124)

关键词：血管支架; 狭窄率; 颈动脉; 数值模拟; 生物力学

分类号：R318.01

出版年·卷·期（页码）：2019·38·3（235-239）

摘要：

目的研究在不同斑块类型的理想化狭窄颈动脉模型中新型锌合金支架的受力变形情况,为新型锌合金支架的设计与应用提供科学的参考意见。方法运用 Pro / E 三维建模软件构建理想化的50%狭窄率血管模型和一种 I 型连接筋血管支架;利用 ABAQUS 有限元分析软件,模拟支架受相同位移扩张条件作用下分别在钙化和非钙化斑块的理想化狭窄血管中的扩张过程。通过计算支架狗骨头率和残余狭窄率评估支架的支撑性能? 结果在斑块材料属性分别为钙化和非钙化的模型中,支架扩张阶段的最大应力分别为 433.4 MPa，432.4 MPa,回弹阶段的最大应力值分别为 266.1 MPa，259.4 MPa;支架狗骨头率分别为 44.5%，33.3%,血管残余狭窄率为 40.8%，30.2% 。结论支架在扩张过程中受到的von Mises 应力都小于材料的应力强度极限,且血管狭窄率都有明显的下降，对于两种斑块类型的狭窄血管,新型锌合金支架都起到了一定的支撑作用。

Objective To study the deformation of new zinc alloy stents in idealized stenotic blood vessel models of different plaque types,and to provide scientific reference for the design and application of new zinc alloy stents.Methods Three?dimensional modeling method was used to construct idealized stenotic vascular model and a I?type connecting vascular stent. Finite element analysis software ABAQUS was used to simulate the process of stent expansion in an idealized stenosis with either calcified or non?calcified plaque and thestenosis rate of 50%.Results In the models with calcified and non?calcified plaque,the maximum stress during the stent expansion phase was 433.4 MPa and 432.4 MPa respectively,and the maximum stress values during the recoiling phase were 266.1 MPa and 259.4 MPa respectively. The dog?bone rate was 44.5% and 33.3% respectively, the residual stenosis rate was 40.8% and 30.2% respectively. Conclusions The von Mises stress of the stent during the expansion process is less than thestrength limit of the material, and the stenosis rate is significantly decreased.For the two types of plaque stenosis,the new zinc alloy stents have played a supporting role to achieve therapeutic effect,which provides guidance and reference for the development of zinc alloy stents.

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