北京生物医学工程

基于粉雾剂的宫颈给药装置结构设计

Structural design of cervical drug delivery device based on powder

作者：吴山山石更强武杰周泽潘肖林

单位：上海理工大学医疗器械与食品学院(上海 200093)

关键词：粉雾剂; 宫颈; 结构设计; 流体力学; 参数计算

分类号：R318.04

出版年·卷·期（页码）：2019·38·3（240-245）

摘要：

目的为了克服传统宫颈给药方式存在的剂型缺陷,本文设计了一种基于粉雾剂的宫颈给药装置,并通过结构设计使该装置能够满足一般粉雾剂药物的给药作用,将粉雾剂药物送达人体病变位置.方法通过模拟现有吸入粉雾剂的装置结构,设计此宫颈给药装置,使粉雾剂均匀喷洒在人体宫颈内,以便于人体宫颈黏膜吸收粉雾剂药物.应用流体力学计算此装置所要求提供的压强参数,同时通过ANSYS 软件定性分析该装置在规定参数下的可行性。结果装置在气流速度 60 L / min,出口压力 1 MPa状态下可以使粉雾剂达到很好的湍流状态,利于粉雾剂的分散。结论该装置能够满足一般粉雾剂的给药要求,对粉雾剂的分散效果明显。

Objective In order to overcome the defects of the conventional vaginal administration, a vaginal drug delivery device for powder is designed .The structural design of the device is capable of meeting the administration of general powder, drugs are delivered to human lesions. Methods The design for the cervix device is accomplished by simulating the structure of the existing inhalation powder, the powder evenly sprayed in the cervix, in order to facilitate the body’ s cervical mucosal absorption of powder drugs. And the pressure parameters required by this device are calculated by hydrodynamics, the feasibility of the device under the specified parameters is qualitatively analyzed by ANSYS. Resluts In the state of air flow rate 60 L / min, outlet pressure 1 MPa, the device can allow the powder to reach a severe turbulence, conducive to the dispersion of powder. Conclusions The device can meet the requirements of the administration of general powder, the dispersion effect of the powder is obvious.

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