北京生物医学工程

肝癌微波消融中热损伤参数分析

Analysis of thermal damage parameters in microwave ablation of liver cancer

作者：赵金哲王娟沐勇杰晋晓飞钱志余李韪韬刘珈

单位：南京航空航天大学自动化学院生物医学工程系(南京 211106) 湖南省肿瘤医院/中南大学湘雅医学院附属肿瘤医院(长沙 410013)

关键词：微波消融；肝脏；热损伤；动力学；阿伦尼乌斯模型；活化能

分类号：R318；R735.7

出版年·卷·期（页码）：2019·38·4（392-399）

摘要：

目的肝癌微波消融研究中，局部热损伤监测和消融仿真计算通常采用Arrhenius模型进行热损伤分析，该模型主要包括活化能Ea和频率因子A两个热损伤参数，然而现有肝脏热损伤参数缺少动力学特性和预测效果对比分析。方法本文采用Arrhenius模型从不同参数所描述的损伤速率和不同温度下的损伤进程方面阐述了其差别，并通过微波消融实验过程的温度数据分析了其对消融损伤的预测效果。结果分析数据表明，Ea（J/mol?1）和A（s?1）分别为2.769×105和5.51×1041、 2.577×105和7.39×1039、1.200×105和4.016×1017的3组参数较适用于消融边界处的损伤计算。结论本文对不同参数的对比有助于指导肝癌消融研究中合理选择热损伤参数进行热损伤分析，从而提高消融手术计划和术中疗效评估的准确性。

Objective In microwave ablation study of liver cancer, Arrhenius model of thermal damage which includes two parameters of activation energy Ea and frequency factor A, is frequently used in microwave ablation simulation and monitoring of local tissue damage. However, analysis of kinetic properties and damage prediction for thermal damage parameters of liver is in need. Methods This paper discussed different thermal damage parameters of liver on the aspects of damage accumulation rate and kinetic damage process under constant temperatures using Arrhenius model, and validated their damage predictions using temperature history from microwave ablation experiments. Results Comparative analysis showed that the parameters of Ea (J/mol) and A (s?1) which were 2.769×105 and 5.51×1041, 2.577×105 and 7.39×1039, 1.200×105 and 4.016×101 could be used for damage predictions on ablation boundary. Conclusions Parameter comparison in this paper provides guidance for thermal damage analysis in ablation studies of liver cancer to improve the accuracy of preoperative surgical planning and intraoperative assessment.

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