北京生物医学工程

个性化颅内动脉瘤患者脑动脉血管三维容积重建及其应用

Three-dimensional volume reconstruction of cerebral arteries for an individual patient with intracranial aneurysm and its application

作者：丁金立王海阔马国峰张勇苗成鹏段云云张磊

单位：首都医科大学附属北京天坛医院放射科（北京 100050）

关键词：三维容积重建; 脑动脉瘤; 计算机断层扫描血管造影; 平滑技术; 迭代

分类号：R318.01

出版年·卷·期（页码）：2020·39·2（117-122）

摘要：

目的对个性化颅内动脉瘤患者动脉瘤周围脑动脉血管进行三维容积重建，探索平滑迭代次数对三维模型的影响。方法针对个性化颅内动脉瘤患者，通过Philips公司的256排iCT进行计算机断层扫描血管造影(computed tomography angiography, CTA)，基于256层头部连续断层图像，利用Mimics商业软件进行三维图像容积重建，获取动脉瘤周围动脉血管的三维解剖结构，对重建模型表面进行6次平滑处理，对比分析3D模型的瘤体直径与2D切片图像测得的瘤体直径，评估3D模型的精确性。结果通过三维容积重建方法得到了动脉瘤周围的颈内动脉C2-C7段、大脑中动脉、大脑前动脉等血管的三维容积模型。平滑迭代次数为3时，模型表面较平滑，颈内动脉血管直径为3.82～5.64 mm，双侧大脑中动脉血管直径2.31～3.83 mm，大脑前动脉血管可见多级分支，动脉瘤长径14.70mm和短径10.32mm。动脉瘤瘤体的长径和短径与2D图像上的测量结果相比误差均在4%以内。结论利用三维容积重建技术所得的动脉瘤周围脑血管模型提供了较二维图像更直观的解剖显示和更好的后处理优势；过度平滑处理会导致三维重建模型尺寸与实际瘤体出现偏差，合理选择平滑迭代次数对三维模型的精确重建具有实际意义。

Objective To carry out the three-dimensional volume reconstruction of cerebral arteries for an individual patient with intracranial aneurysm, and to discuss the influence of different iterations of smooth technology on the reconstrued model. Methods Philips 256 iCT was employed to perform computed tomography angiography (CTA), from which 256 slices were utilized for three-dimensional (3D) volume reconstruction by using the commercial software Mimics. Six iterations of smooth technology were performed on the reconstrued model. The longest and shortest diameters of the aneurysm was measured in the 3D model and compared with the results measured from 2D slices, to evaluate the precision of the smoothed models. Results The three-dimensional model of cerebral arteries and the intracranial aneurysms reconstructed after 3 iterations of smooth technology were measured. They included internal carotid artery of 3.82 mm-5.64 mm, bilateral middle cerebral artery of 2.31 mm-3.83 mm, multi-branches of anterior cerebral artery, intracranial aneurysm ( with longest diameter of 14.70 mm and shortest diameter of 10.32 mm). All the diameter-error ranges of the aneurysm were controlled within 4%. Conclusions The 3D model reconstructed by the volume reconstruction provides a more visual display than the original CT images. Application of excessive iterations of smooth technology increase the error of reconstrued model. Appropriate iterations of smooth technology is important for accurate 3D reconstruction.

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