北京生物医学工程

纳米纤维素复合材料在骨科领域的研究进展

Research progress of the nanocellulose composite in orthopedics

作者：康然刘金龙

单位：中国人民解放军陆军第八十集团军医院（山东潍坊 261042）

分类号：R318.08

出版年·卷·期（页码）：2020·39·3（317-320）

摘要：

纳米纤维素因其良好的可降解性及组织相容性，近年来在生物医药领域尤其是骨科领域备受关注。纳米纤维素与传统生物材料复合，能够显著改善复合材料的抗压强度及抗溃散性；在同骨科修复材料的复合中，不仅能使引入的生物活性物质有效地定植，而且能模拟生理性的细胞外基质，为活性物质的生长分化提供生理基础。本文结合近年来纳米纤维素复合材料在伤口愈合、骨缺损修复及软骨再生等骨科领域中材料复合方式、改良原理以及体内外试验等方面的研究进展进行综述，为纳米纤维素复合材料的临床应用提供参考。

Nanocellulose attracts research interest in biomedicine area especially orthopedics, because of its good histocompatibility and degradability. Besides, when combined with other biomaterial, both the compressive strength and resistance in collapse of the composites are improved. It's worth noting that the composites of nanocellulose and bone defect repairing material can not only efficiently promote the colonization of introduced bioactive material, but also act as extracellular matrix to support the bioactive material growth and differentiation.This paper focuses on the study of nanocellulose composites used in orthopedics such as would healing, bone defect repairing, and cartilage regeneration. The fabrication method, function principle and in vivo and in vitro experiment of nanocellulose composite are reviewed in detail，we expect to provide a reference for clinical application.

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