北京生物医学工程

基于Golay互补序列的20 MHz眼科超声成像方法

20 MHz ophthalmic ultrasound imaging based on golay complementary sequence

作者：王晓春杨军计建军周盛

单位：中国医学科学院生物医学工程研究所（天津 300192）

分类号：R318

出版年·卷·期（页码）：2021·40·2（167-173）

摘要：

目的研究一种新型20 MHz眼科超声扫描成像方法，可在满足临床成像分辨力和声能安全性的前提下，显著提高图像的探测深度，拓展20 MHz超声频段的临床应用范围。方法通过8位Golay互补序列，激励超声换能器产生超声波。回波信息经高速采集与匹配滤波后，采用相邻正、反编码扫描线数据复用的方法交替相加，完成解码运算。实现在保证图像扫描线数和扫查帧频的前提下，实时显像。最后通过钨丝靶线和仿组织超声体模实验验证了新的成像方法在保持原有分辨能力与扫描帧频不变的前提下，提高了图像的探测深度。结果与传统单脉冲模式相比，Golay互补编码模式成像中轴向分辨率与侧向分辨率分别达到80 μm和150 μm，小信号探测深度增加约0.5 cm，图像信噪比也得到显著改善。结论基于Golay互补序列实现20 MHz眼部组织超声成像，相对于传统成像方式可极大改善图像质量，具有很好的临床应用前景。

Objective To study a new 20MHz ophthalmic ultrasound scanning imaging method, which can significantly improve the detection depth of the image and expand the clinical application range of 20MHz ultrasound frequency band on the premise of meeting the clinical imaging resolution and sound energy safety. Methods An 8-bit Golay complementary sequence was used to excite the ultrasonic transducer to generate ultrasonic wave. After high-speed acquisition and matched filtering, the echo information was added alternately by the method of adjacent forward and inverse coded scan line data multiplexing to complete decoding operation. Real time imaging can be realized on the premise of ensuring the number of image scanning lines and scanning frame rate. Finally, experiments on tungsten wire target lines and tissue-mimiking ultrasound phantom verified that the new imaging method can improve the detection depth of the image while keeping the original resolution and scanning frame rate unchanged. Results Compared with single-pulse mode, the axial resolution and lateral resolution of Golay complementary coding mode were 80 μm and 150 μm respectively, and the detection depth of small signal was increased by about 0.5 cm, and the signal-to-noise ratio of the image was also significantly improved. Conclusions Compared with the traditional imaging methods, the image quality of 20MHz eye tissue ultrasound imaging based on Golay complementary sequence can be greatly improved, which has a good clinical application prospect.

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