北京生物医学工程

同种异体与动物源性补片的力学性能比较

Comparison of mechanical properties between allogeneic and animal derived patches

作者：李崇崇刘丽王硕韩倩倩王春仁李静莉

单位：中国食品药品检定研究院(北京 102629)

关键词：同种异体补片；猪源性补片；牛源性补片；力学性能

分类号：R318.01

出版年·卷·期（页码）：2021·40·2（181-184）

摘要：

目的比较同种异体和动物源性补片的力学性能，为相关行业的产品研发和临床使用提供参考。方法使用力学实验设备对同种异体补片、猪源性补片、牛源性补片的拉伸强度、断裂伸长率、缝合强度进行测试，并对实验数据进行统计分析。结果力学测试结果显示，猪源性补片在拉伸强度和缝合强度两个方面与同种异体补片无显著差异（分别为9.31 MPa vs 9.37 MPa，P>0.05；24.48 N vs 22.18 N，P>0.05），而牛源性补片的拉伸强度较高（22.73 MPa，P<0.01），缝合强度较低（11.97 N，P<0.01），在断裂伸长率方面同种异体补片明显高于两种动物源性补片(68.49% vs 40.18% vs 31.61%，P<0.01)。结论猪源性补片与同种异体补片具有部分的力学相近性，但同种异体补片在断裂伸长率方面与动物源性补片具有显著差异。

Objective To compare the mechanical properties of allogeneic and animal derived patches, so as to provide reference for product development and clinical use in related industries. Methods The tensile strength, elongation at break and suture strength of allogeneic, porcine and bovine patches were tested by mechanical experimental equipment, and the experimental data were statistically analyzed. Results The mechanical test results showed that there was no significant difference in tensile strength and suture strength between porcine and allogeneic patch (9.31 MPa vs 9.37 MPa, P > 0.05; 24.48 N vs 22.18 N, P > 0.05, respectively). The tensile strength of bovine patch was higher (22.73 MPa, P < 0.01), and the suture strength was lower (11.97 N, P < 0.01). The elongation at break of allogeneic patch was significantly higher than that of two kinds of animal derived patch (68.49% vs 40.18% vs 31.61%, P < 0.01). Conclusions Certain of the mechanical properties of porcine and allogeneic patch are similar, yet the elongation at break of allogeneic patch is significantly different from that of animal patches.

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