北京生物医学工程

基于指脉的血液黏度无创检测的可行性分析

Feasibility analysis of non-invasive measurement of microvascular blood viscosity based on finger pulse

作者：王雷张新宇杨琳孟煜

单位：北京工业大学医院(北京 100124) 北京工业大学环境与生命学部智能化生理测量与临床转化北京市国际科研合作基地 (北京 100124) 通信作者：杨琳。E-mail：yanglin@bjut.edu.cn

关键词：血液黏度；光电容积脉搏波；血液生化指标；无创检测

分类号：R318.04

出版年·卷·期（页码）：2022·41·1（68-72）

摘要：

目的通过无创的微血管血液黏度与低切血液黏度之间的相关性，探究基于指脉的血液黏度无创检测的可行性。方法首先采集被测者的静脉血、指尖光电容积脉搏波及生理信息；然后使用指脉波形面积拟合微血管半径，通过泊肃叶定律公式计算无创的微血管血液黏度；最后用SPSS软件分析微血管血液黏度计算值与全血黏度的相关性以及血液黏度与基础生理因素、血液生化因素之间的相关性。结果微血管血液黏度计算值与低切血液黏度呈正相关。体重、腰围、体表面积、总胆固醇与微血管血液黏度计算值、低切血液黏度呈正相关；高密度脂蛋白与微血管血液黏度计算值、低切血液黏度呈负相关。结论通过指脉无创检测出来的微血管血液黏度，与有创检测出来的低切血液黏度之间的正相关性以及二者状态变化规律的一致性表明，基于指脉的血液黏度无创检测具有一定的可行性。

Objective To analyze the correlation between the calculated value of microvascular blood viscosity and the whole blood viscosity at a low shear rate, and to explore the feasibility of the non-invasive blood viscosity detection method based on the finger pulse. Methods First，we collected venous blood, photoplethysmography and physiological information. Then，the pulse wave area was used to fit the microvascular radius, poiseuille law formula was used to calculate the microcirculation blood viscosity. Finally，the correlation between calculated values of microvascular blood viscosity and whole blood viscosity at a low shear rate, and the correlation between blood viscosity with basic physiological factors and blood biochemical factors were analyzed by SPSS software. Results The calculated value of microvascular blood viscosity was positively correlated with whole blood viscosity at a low shear rate. Body weight, waist circumference, body surface area and total cholesterol were positively correlated with the calculated value of microvascular blood viscosity and whole blood viscosity. High density lipoprotein was negatively correlated with the calculated values of microvascular blood viscosity and whole blood viscosity at a low shear rate. Conclusions The positive correlation and consistent state change between the microvascular blood viscosity detected by non-invasive method and the whole blood viscosity at a low shear rate detected by invasive method indicate that the non-invasive detection of blood viscosity based on finger pulse is feasible.

参考文献：

[1]?中国心血管健康与疾病报告2019[J].心肺血管病杂志，2020，39(9)：1145-1156.

Annual report on cardiovascular health and diseases in China 2019[J]. Journal of Heart Lung and Blood Diseases, 2020, 39(9): 1145-1156.

[2]?Gori T. Endothelial function, fluid dynamics, hemorheology implications for clinical and preclinical vascular disease and implications for the ESCHM[J]. Clinical Hemorheology and Microcirculation, 2016, 64(4): 521-524.

[3]?Saldanha C. Hemorheology, microcirculation and microcirculation[J]. Revista Portuguesa de Cardiologia, 2020, 39(1): 25-26.

[4]?Hamlin SK, Benedik PS. Basic concepts of hemorheology in microvascular hemodynamics[J]. Critical Care Nursing Clinics of North America, 2014, 26(3):337-344.

[5]?Kanaris AG, Anastasiou AD, Paras SV. Modeling the effect of blood viscosity on hemodynamic factors in a small bifurcated artery[J]. Chemical Engineering Science, 2012, 71(12): 202-211.

[6]?聂永梅，成敏，陈槐卿，等. 动脉粥样硬化进程中血脂、血流动力学指标和血管内膜的动态变化[J]. 生物医学工程学杂志，2005,22(1): 10-14.

?Nie YM, Cheng M, Chen HQ, et al. Dynamic alteration of blood lipid and hemodynamics parameters and vascular intima in the process of atherosclerosis[J]. Journal of Biomedical Engineering, 2005,22(1):10-14.

[7]?Velcheva I, Antonova N, Dimitrova V, et al. Plasma lipids and blood viscosity in patients with cerebrovascular disease[J]. Clinical Hemorheology and Microcirculation, 2006, 35(1-2): 155-157.

[8]?Vazquez BY, Cabrales P, Tsai AG, et al. Nonlinear cardiovascular regulation consequent to changes in blood viscosity[J]. Clinical Hemorheology and Microcirculation, 2011, 49(1/4): 29-36.

[9]?Balakumar P, Maung-U K, Jagadeesh G. Prevalence and prevention of cardiovascular disease and diabetes mellitus[J]. Pharmacological Research, 2016: 600-609.

[10]?Chandra P, Bhave R. Assessing the risk factors associated with cardiovascular disease[J]. European Journal of Preventive Cardiology, 2018, 25(9):?932-933.

[11]?Lowe G, Rumley A, Norrie J, et al. Blood rheology, cardiovascular risk factors, and cardiovascular disease: the west of scotland coronary prevention study[J]. Thrombosis and Haemostasis, 2000, 84(4): 553-558.

[12]?吴西，高纬，周明莎，等. 血液黏度测量技术标准化问题及研究进展[J]. 现代医药卫生, 2010, 26(13): 2006-2008.

Wu X, Gao W, Zhou MS, et al. Standardization of blood viscosity measurement technology and its research progress[J]. Journal of Modern Medicine & Health, 2010, 26(13): 2006-2008.?

[13]?Wiewiora M, Mertas A, Nowowiejska W, et al. The effects of venous hemodynamics on angiogenesis in morbid obese[J]. Clinical Hemorheology & Microcirculation, 2018, 71(3): 347-356.?

[14]?Schneditz D, Kenner T. Noninvasive Assessment of Vascular Function [J]. Contributions to Nephrology, 2005, 39: 306-314.

[15]?罗志昌,张松,杨益民. 脉搏波的工程分析与临床应用[M]. 北京：科学出版社，2006.

[16]?张俊利，蔺嫦燕. 容积脉搏波的检测方法及其在评价心血管功能方面的应用[J]. 北京生物医学工程，2007,26(2): 220-224.

Zhang JL, Lin CY. Measurement of volume pulse wave and the application in evaluation of the cardiovascular fuction[J]. Beijing Biomedical Engineering, 2007,26(2): 220-224.

[17]?Tripolino C, Irace C, Carallo C, et al. Body fat and blood rheology: Evaluation of the association between different adiposity indices and blood viscosity[J]. Clinical Hemorheology and Microcirculation, 2017, 65(3): 241-248.

[18]?Brun JF, Varlet-Marie, Romain AJ, et al. Interrelationships among body composition, blood rheology and exercise performance[J]. Clinical Hemorheology and Microcirculation,2011,49(1-4): 183-197.

[19]?Carallo C, Irace C, Esposito T, et al. The effect of HDL cholesterol on blood and plasma viscosity in healthy subjects[J]. Clinical Hemorheology and Microcirculation, 2013, 55(2): 223-229.

[20]?Yalcin O, Ortiz D, Williams AT, et al. Perfusion pressure and blood flow determine microvascular apparent viscosity[J]. Experimental physiology, 2015, 100(8): 977-987.

[21]?Sun G, Yang L, Wang WW, et al. An Algorithm for the noninvasive and personalized measurement of microvascular blood viscosity using physiological parameters[J]. BioMed Research International, 2020, 2020: 7013212-7013212.

[22]?杨琳，张松，杨益民，等. 基于桡动脉脉搏波血流动力学检测的心输出量计算修正[J]. 北京生物医学工程，2007, 26(6): 575-578, 592.

Yang?L, Zhang S, Yang YM, et al. Rectification of the cardiac output computation based on radial pulse wave hemodynamic detecting[J]. Beijing Biomedical Engineering, 2007, 26(6): 575-578, 592.

[23]?Guiraudou M, Varlet-Marie, E, Burn JF, et al. Obesity-related increase in whole blood viscosity includes different profiles according to fat localization[J]. Clinical Hemorheology and Microcirculation, 2013, 55(1): 63-73.

[24]?孙伟光，卢婷利，校玉山，等. 某高校3860名体检教职工BMI与血脂血糖及血尿酸生化指标的关系[J]. 公共卫生与预防医学，2021, 6(2): 64-67.

Sun WG, Lu TL, Jiao YS, et al. Analysis of the relationship between BMI and blood lipids, blood glucose and?blood uric acid in 3 860 employees in a university[J]. Journal of Public Health and Preventive Medicine, 2021, 6(1): 64-67.

[25]?聂璐，韩春姬，全贞玉. 血脂与血尿酸及血液黏度的相关性研究[J].中国慢性病预防与控制，2011, 19(6): 596-598.

Nie L, Han CJ, Quan ZY. Relationship of blood lipid with blood uric acid and viscosity[J]. Chinese Journal of Prevention and Control of Chronic Diseases, 2011, 19(6):596-598.

服务与反馈：

【文章下载】【加入收藏】

提示：您还未登录，请登录！点此登录