北京生物医学工程

癫痫外科结构磁共振常见分析方法研究进展

Common analysis methods for structural MRI in epilepsy surgery

作者：莫嘉杰张建国胡文瀚张凯

单位：首都医科大学附属北京天坛医院神经外科（北京 100070） 首都医科大学北京市神经外科研究所（北京 100070） 通信作者：张凯。E-mail：zhangkai62035@sina.com

关键词：神经影像；计算模型；统计分析；多重校正

分类号：R318.04

出版年·卷·期（页码）：2022·41·1（97-103）

摘要：

结构磁共振（magnetic resonance imaging，MRI）对癫痫的诊治至关重要，尤其是考虑行癫痫外科治疗时。但癫痫外科部分常见病理类型（如皮质发育不良、海马硬化）在常规阅片中表现隐蔽，给临床工作带来了巨大挑战。因此，结合利用神经影像后处理及统计分析方法，对影像数据进行分析、建模和解释，进一步挖掘其量化识别和分析致痫灶的价值，将有利于增加其临床指导价值。本文将针对目前癫痫外科结构磁共振常用的分析方法、计算模型和统计应用的研究进展进行综述。

Structural magnetic resonance imaging( sMRI) is of fundamental important to the diagnosis and treatment of epilepsy, particularly when surgery is being considered. However, some common pathological types of epilepsy surgery ( such as focal cortical dysplasia, hippocampal sclerosis) are subtle in conventionally visual interpretation, which brings great challenges to presurgical workup. Therefore, the neuroimaging data analysis, modelling and interpretation using post-processing and statistical analysis methods will help to quantitatively identify and analyse the epileptogenic focus as well as increase its clinical value. The present article will introduce the analysis methods, calculation models and statistical applications of MRI in epilepsy surgery.

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