北京生物医学工程

弹簧圈填充密度对乙状窦憩室内血流动力学的影响

Effect of coil density on hemodynamics in sigmoid sinus diverticulum

作者：刘莉穆振霞薛晓飞黄素琴吕涵高斌赵鹏飞丁贺宇王振常

单位：北京工业大学环境与生命学院（北京100124） 首都医科大学北京友谊医院放射科(北京100050) 通信作者：高斌。E-mail：gaobin@bjut.edu.cn

分类号：R318.01

出版年·卷·期（页码）：2022·41·3（221-227）

摘要：

目的从血流动力学的角度，研究弹簧圈填充密度对乙状窦憩室内血流动力学的影响规律。方法首先根据一名搏动性耳鸣患者的CTA影像数据建立个性化的乙状窦血管几何模型，然后采用连续的3D Timoshenko梁单元对弹簧圈离散化，建立不同填充密度的弹簧圈模型，最后采用瞬态计算流体力学(computational fluid dynamics , CFD)方法研究弹簧圈栓塞后憩室内血流动力学变化。采用血管壁面压力、壁面剪切力、血流速度流线和憩室低流速区域体积占比等参数来对比不同填充密度下憩室的血流动力学变化。结果在低填充密度下随着填充密度的增大，憩室平均壁面压力和憩室平均壁面剪切力降低。高填充密度下，增大填充密度以上指标变化不明显。结论高的填充密度有利于憩室内血栓形成的血流动力学环境，憩室内低流速区域体积占比增大，有利于憩室内血栓形成的血流动力学环境。

Objective To explore the effect of coil packing density on hemodynamics in diverticulum from the perspective of hemodynamics. Methods According to the CTA image data of a patient with pulsatile tinnitus, a personalized geometric model of sigmoid sinus vessel was established. Then the coil and stent models were established by finite element method. The coil centerline was meshed with an 3D Timoshenko beam element method. Coils model with different packing densities were established. Transient computational fluid dynamics (CFD) method was used to simulate the hemodynamics of diverticulum embolization with coils. The wall pressure, wall shear stress, blood velocity streamlines and the proportion of low flow velocity of diverticulum were analyzed and compared to evaluate the hemodynamic changes of diverticulum. Results At low packing density, the , increased with the increase of packing density, the wash of blood flow on blood vessel wall decreased with the increase of packing density. Under high packing density, the change of the above indexes was not obvious. Conclusions Higher packing density is conducive to the hemodynamic environment of thrombosis in diverticulum. The volume proportion of low velocity area in diverticulum increases, which is conducive to the hemodynamic environment of thrombosis in diverticulum.

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