北京生物医学工程

新生儿亚低温治疗仪温控系统研究

Research on temperature control system of neonatal mild hypothermia therapeutic instrument

作者：朱宇科吴海啸刘广清李海磊胡燕海

单位：宁波大学机械工程与力学学院（浙江宁波315211） <br />宁波戴维医疗器械股份有限公司（浙江宁波315712）<br />通讯作者：胡燕海，教授。E-mail:huyanhai@nbu.edu.cn

分类号：R318.6 

出版年·卷·期（页码）：2022·41·5（488-494）

摘要：

目的针对国内市场上的亚低温治疗仪控温精度不高、体积较大等问题，结合新生儿缺氧缺血性脑病亚低温治疗的特点，提出一套控温准确、便携性好的新生儿专用亚低温治疗仪温控系统。方法温控系统以半导体制冷片作为热源，对患儿进行全身降温治疗。建立水温控制模型和体温反馈模型，以阶跃响应法辨识模型参数。基于模型采用自抗扰控制算法和非线性PI算法建立水温控制系统与体温反馈控制系统，并使用粒子群算法搜寻最佳控制器参数。最后，引入暖体假人系统用于模拟婴儿进行亚低温治疗实验。结果采用半导体制冷方案的新生儿亚低温治疗仪体积为28 L，质量仅为7 kg。水温控制系统调节速度快，无明显超调及稳态误差，水温控制精度为±0.1℃；体温反馈控制系统控温准确，受干扰后恢复稳态的时间短。结论本文提出的新生儿亚低温治疗仪温控系统可实现新生儿亚低温治疗功能，与传统设备相比在便携性、温控精度上均有显著提升，具有应用的价值。

Objective In view of the problems of low temperature control precision and large volume of mild hypothermia therapeutic instrument in the domestic market, combined with the characteristics of mild hypothermia treatment for neonates with hypoxic ischemic encephalopathy, a temperature control system of mild hypothermia therapeutic instrument for neonates with accurate temperature control and good portability was proposed. Methods The temperature control system uses semiconductor refrigeration sheets as the heat source to cool the whole body of the child. The water temperature feedback model and the warm body temperature feedback model are established, and the step response method is used to identify the models. Based on the model, the water temperature control system and the body temperature feedback control system are constructed using active disturbance rejection control and non-linear PI algorithm, and the particle swarm algorithm is used to adjust the controller parameters. Finally, the warm body dummy system is used to simulate infants for sub-hypothermia treatment experiments. Results The volume and weight of the neonatal mild hypothermia treatment instrument using semiconductor refrigeration scheme are 28 L and 7 kg respectively. The water temperature control system has the advantages of fast adjustment speed, no obvious overshoot and steady-state error, and the temperature control accuracy is within ±0.1℃. The body temperature feedback control system is accurate in temperature control, and it takes a short time to return to a steady state after being disturbed. So the function of neonatal mild hypothermia treatment can be achieved well. Conclusions The temperature control system of the neonatal mild hypothermia treatment instrument proposed in this paper has good portability and temperature control effect, and has application value.

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