北京生物医学工程

糖尿病患者“寸、关、尺”脉搏压力波形的频谱分析

Frequency spectrum analysis on pressure pulse wave of diabetes mellitus at Cun, Guan and Chi based on TCM

作者：李本森卢意成龚文波缪馥星

单位：宁波大学冲击与安全工程教育部重点实验室(浙江宁波 315211)<br />宁波市中医医院王晖工作室(浙江宁波 315000)<br />通信作者：缪馥星，教授。E-mail: miaofuxing@nbu.edu.cn

分类号：R318.04

出版年·卷·期（页码）：2023·42·2（117-123）

摘要：

目的对糖尿病受试者的脉搏信号进行频域分析，研究糖尿病受试者脉搏波形在频域范围内的特性，探讨从频域特征判断糖尿病的可能性。方法应用三通道中医脉象仪，通过中医切脉定位寸、关、尺，采集糖尿病受试者和健康受试者的脉象信息，对采集的脉象信息进行频域分析，并对功率谱密度的峰值进行指数拟合、统计糖尿病受试者与健康受试者的频域分布范围、峰值个数，以及低次谐波偏差、高次谐波偏差、总谐波偏差。结果通过对数据的统计分析、与健康受试者的数据对比发现：糖尿病症受试者的脉搏波频率分布范围较大，谐波峰值的指数衰减特征与健康受试者具有很大不同，同一受试者寸、关、尺同样具有很大不同，且糖尿病症受试者的第一主峰的分布频率要比健康受试者的高。结论糖尿病症受试者与健康受试者频率分布范围不同，高次谐波偏差以及寸位置的第一主峰频率可以作为区分健康受试者以及糖尿病症受试者的特征参数。临床测量验证了寸、关、尺脉搏波信号的不同，也恰佐证了中医脉诊过程中，区别寸、关、尺脉象的指代意义，并综合诊断的中医实践。本文的初步研究结果将对进一步认识糖尿病症及其中医临床脉诊的科学化奠定基础。

Objective The pulse signals of diabetic subjects were analyzed in the frequency domain to study the characteristics of their pulse waveforms in the frequency domain and to explore the possibility of judging diabetes from the characteristics of the frequency domain. Methods The pulse signals of diabetic subjects and the pulse wave characteristics of clinical pulses of diabetic subjects were collected by using the three-channel traditional Chinese medicine pulse instrument, and the collected pulse signals were analyzed in the frequency domain, and the power spectrum density was fitted and statistically analyzed. The frequency domain distribution range, peak number, low-order harmonic deviation（LHD）, high-order harmonic deviation（HHD）, and total harmonic deviation（THD） of diabetic subjects and healthy subjects were counted. Results Through statistical analysis of the data and compared with the data of healthy subjects, it is found that the pulse wave frequency distribution range of diabetic subjects is larger, the exponential attenuation characteristics of the harmonic peak are very different from those of healthy subjects, the Cun, Guan, and Chi for the same subjects are also very different, and the distribution frequency of the first main peak of diabetic subjects is higher than that of healthy subjects. Conclusions The frequency distribution range of diabetic subjects is different from that of healthy subjects. The HHD and the frequency of the first main peak at Cun can be used as characteristic parameters to distinguish healthy subjects from diabetic subjects. The clinical measurement also verifies the difference in pulse wave signals at Cun, Guan, and Chi by the clinical measurement. It also proved that traditional Chinese medicine practice has scientific property by distinguishing the referential meaning of Cun, Guan, and Chi pulses in the process of pulse diagnosis. The present research results will lay the foundation for further understanding of diabetes and its Chinese medicine clinical pulse diagnosis.

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