北京生物医学工程

冠状动脉狭窄几何特征参数影响跨狭窄压力损失的统计学分析

Statistical analysis on geometric characteristic parameters of coronarystenosis affecting the cross-stenosis pressure loss

作者：邵圣达周鑫鑫丁永鑫张佳玉耿佃桥

单位：东北大学冶金学院(沈阳 110819) <p>东北大学材料电磁过程研究教育部重点实验室(沈阳110819)<br />通信作者:耿佃桥,副教授。E-mail: neugeng@163.com</p>

关键词：冠状动脉狭窄；血流储备分数；数值模拟；正交试验；方差分析

分类号：R318.01

出版年·卷·期（页码）：2023·42·2（158-163）

摘要：

目的分析狭窄偏移、管腔离心率、狭窄弯曲度对跨狭窄压力损失的影响,筛选其中关键几何特征参数。方法本研究采用计算流体力学方法对不同几何特征参数下冠状动脉狭窄段内的血液流动开展数值模拟。基于模拟所得跨狭窄压力损失开展统计学分析,考察了各几何特征参数对跨狭窄压力损失的主效应及彼此间的交互效应。结果狭窄偏移及狭窄弯曲度对跨狭窄压力损失影响显著:狭窄偏移与狭窄率、狭窄弯曲度与狭窄长度、狭窄弯曲度与狭窄率交互效应显著:管腔离心率对跨狭窄压力损失的影响一定范围内可忽略。结论本研究结果可为现有冠状动脉计算机断层扫描血流储备分数经验公式引入新的几何特征参数提供理论基础。

Objective This study aims to analyze the effects of stenosis offset , lumen eccentricity andstenosis curvature on the cross-stenosis pressure loss, and select the key geometric characteristic parametersMethods In this study ,the computational fluid dynamics ( CFD) method was used to simulate the blood flow inthe coronary stenosis section under different geometric characteristic parameters. Based on the simulated cross:stenosis pressure loss statistical analysis was carried out to investigate the main effect of geometric characteristi(parameters on cross-stenosis pressure loss and the interaction effect between parameters. Results The stenosis offset and stenosis curvature had a significant effect on thesignificantcross-stenosis pressureloss. Therewereinteraction effects between stenosis offset andstenoslsrate , stenosis curvature and stenosis length , and stenosisstenosis rate. The effects of lumencurvature andeccentricity on the cross-stenosis pressure lloss could be ignored within a certain range.Conclusions This work may provide a theoretical basis for introducing newgeometric characteristic parameters into the existing empirical equation of computed tomography angiography.derived fractional flow reserve ( FFR_CT).

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