北京生物医学工程

心脏瓣膜生物力学及相关建模方式的研究进展

Research progress of heart valve biomechanics and related modeling methods

作者：孟丑拴洪洋姜华张宾

单位：河北北方学院附属第一医院（河北张家口 075000）<br />通信作者：张宾。E-mail:13731312273@163.com

分类号：R318.01

出版年·卷·期（页码）：2023·42·2（212-216）

摘要：

心脏瓣膜生物力学是一个快速发展的、高度临床相关的研究领域。研究表明大多数瓣膜病变是由于瓣膜生物力学改变导致的，因此了解心脏瓣膜与其局部力学环境之间的相互作用对于了解正常瓣膜功能和阐明瓣膜疾病进展至关重要。然而研究这些病变的技术在很大程度上受到了限制，其中缺乏良好的瓣膜力学相互作用模型是限制该领域研究深入开展的主要瓶颈之一。随着数值计算模型、体外模型和动物模型建模技术的飞速发展，心脏瓣膜相关的生物力学和介入治疗研究取得了重大进展。本文对心脏瓣膜的生物学和生物力学及相关模型进行综述，旨在使用跨学科方法加强临床心血管医生对心脏瓣膜疾病的理解。

Heart valve biomechanics is a rapidly developing and highly clinically relevant field of research. Studies have shown that most valve disease is due to altered valve biomechanics, and understanding the interaction between the heart valve and its local mechanical environment is critical for understanding normal valve function and elucidating disease progression. However, the techniques for studying these lesions are largely limited, and the lack of good valve mechanical interaction models is one of the main bottlenecks restricting the in-depth research in this field. With the rapid development of numerical calculation model, in vitro model and animal model modeling technology, significant progress has been made in biomechanics and interventional therapy research related to heart valves. This article reviews the biology and biomechanics of heart valves and related models with the aim of enhancing clinical cardiologists' understanding of heart valve disease using an interdisciplinary approach.

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