Based on erythrocytes senile model in vivo, which developed by using antibody to induce acute homolysis of RBC, the authurs studied the change of osmotic fragility oferythrocytes. The result showed that the osmotic fragility increasing with the increase ofRBC age. It is deduced that the change of osmotic fragility may be related to the changes of the membrane structure and the geometric shapes (the ratios of surface areas tovolumes) of RBCs during their aging.
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