北京生物医学工程

新型聚酯醚材料体内外降解和组织反应 _

Degradation and Tissue Reaction of New Polyester Ether Biomaterial in Vitro and in Vivo

作者：王定国; 胡颖嘉; 郑华; 吴增树;

单位：四川省生物医学材料监测中心;

关键词：聚酯醚; 体内外降解; 组织反应;

分类号：

出版年·卷·期（页码）：1996·1·3（160-164）

摘要：

作者采用凝胶渗透色层法，扫描电镜和光学显微镜观察，对新型聚酯醚（聚癸二酸－丁二醇－聚乙二醇共聚物）生物降解材料进行了体内外降解和体内植入相容性研究。材料在体内１５０天时，该材料重量和分子量丧失５０％左右，２８０天分别丧失８６％和８９％；在此观察期内材料与组织相容性良好。而材料体外降解较体内缓慢，对二者间的差异和可能影响降解的因素进行探讨。并与另一种新型聚酯醚材料（ＤＬ－聚乳酸－聚乙二醇共聚物）进行比较。结果显示聚癸二酸－丁二醇－聚乙二醇共聚物是一种降解周期较长的生物医用可降解材料。

Using gel permeation chromatography and Scanning electron microscopy observed the degradation of new biomaterials polysebacic acid-1, 4-butanediol-poly copolymer in vitro and in vivo. After 150 days the mass loss was 50% and the molecular weight determined with gel permeation chromatography (GPC) showed a reduction to 50%. After 280 days the mass loss was 86% and the molecular weight loss was 89%. It was found that the biocompatibility between the materials and tissue was fine. Degradation of PSBE was faste...

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