北京生物医学工程

降解材料聚乳酸－聚乙二醇生物相容性的研究

A Study on the Biocompatibility of Biodegradable PELA Copolymer

作者：王定国; 郑华; 胡颖嘉; 邱书明;

单位：四川省生物医学材料监测中心;

关键词：降解材料; 聚乳酸－聚乙二醇共聚物; 生物相容性;

分类号：

出版年·卷·期（页码）：1995·1·3（173-177）

摘要：

作者对国产新型生物医用可降解材料ＤＬ—聚乳酸—聚乙二醇共聚物（ＰＥＬＡ）进行了系统的生物学评价。结果表明：降解材料ＰＥＬＡ无全身毒性、无热原和细胞毒性、无溶血（溶血率小于５％）、对皮肤和眼粘膜无刺激、不引起致敬反应、对骨髓多染红细胞无影响。体内植入２８０天，材料基本降解完全，材料周围纤维囊壁厚度逐渐变薄，炎症细胞反应减轻。因此，可认为降解材料ＰＥＬＡ有良好的生物相容性。

A systemic biological evaluation was conducted for a new domestic biodegradable material PELA(Poly D.L-lactide-polyethyleneglycol copolymer).The results showed that PELA had no general toxicity,no reaction of pyrogen,no irritation to the skin and mucous membranes of eyes,no sensitization.The hamolysis rate was less than 5%.There was not effect to polychromatic erythrocyte of mouse bone marrow.The test of subchronic toxicity showed no pernicious effects to mice in one month.It was embedded under skin for nin...

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