蛋白质-蛋白质相互作用在生命活动中起着重要的作用.本文通过整合多个数据源,采用Logistic回归模型,对模式生物酵母所有的蛋白质之间相互作用进行了计算预测,得到了一个酵母蛋白质相互作用的加权网络,结果分析表明本文得到的蛋白质相互作用网络有较高的可靠性.

1. Ito T.Chiba T A comprehensive two-hybrid analysis to explore the yeast protein interactome 2001
2. Uetz P A comprehensive analysis of protein-protein interactions in Saccharomyces cerevisiae 2000(6770)
3. Ho Y Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry 2002
4. Gavin AC Functional organization of the yeast proteome by systematic analysis of protein complexes 2002(6868)
5. Lu LJ Assessing the limits of genomic data integration for predicting protein networks 2005
6. Jansen R A Bayesian Networks Approach for Predicting Protein-Protein Interactions from Genomic Data 2003
7. Cho RJ A Genome-Wide Transcriptional Analysis of the Mitotic Cell Cycle 1998
8. Hughes TR Functional Discovery via a Compendium of Expression Profiles 2000
9. Ashburner M Gene ontology:tool for the unification of biology 2000(1)
10. Mewes HW.Frishman D MIPS:a database for genomes,and protein sequences 2002
11. Stark C.Breitkreutz BJ BioGRID:a general repository for interaction datasets 2006
12. Hastie T.Tibshirani R.Friedman J The Elements of Statistical Learning:Data Mining,Inference,and Prediction 2001
13. Komarek P.Moore AW Making Logistic Regression A Core Data Mining Tool With TR-IRLS 2005
14. Huffner F.Wernicke S.Zichner T Algorithm Engineering For Color-Coding To Facilitate Signaling Pathway Detection 2007
15. Alon N.Yuster R.Zwick U Color-coding 1995(4)
16. Kanehisa M.Goto S KEGG:Kyoto Encyclopedia of Genes and Genomes 2000(1)