目的 研究光学相干层析成像技术(optical coherence tomography,OCT)在新鲜人脑标本上对脑灰质、白质等组织的成像对比,探索其在神经外科的临床应用前景.方法 利用OCT设备, 对手术切除的影像学未见明显异常的颞叶癫痫病患者的颞前叶脑组织进行OCT扫描成像,并将脑灰质、白质的OCT图像进行比较.结果 新鲜人脑组织OCT成像中,灰质较灰暗而光穿透深度较深;白质明亮而光穿透深度较浅.对于大脑表层的成像能辨别出小血管、蛛网膜下腔等结构.结论 OCT图像与生物组织学图像高度关联,不同组织的光学特征也明显不同.新鲜人脑标本的OCT成像上,根据信号强度与衰减特征可以非常清楚地区分脑的白质和灰质.在改进OCT的探头设计和进一步提高分辨率后,可以用于指导神经外科手术.

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