北京生物医学工程

握力刺激强度与运动皮层激活相关性的fMRI研究

Force of Squeezing Related to Motor Cortex Activation: A fMRI Study

作者：成学慧李海云

单位：首都医科大学生物医学工程学院（北京100069）

分类号：

出版年·卷·期（页码）：2010·29·1（30-34）

摘要：

目的研究握力刺激强度与运动皮层激活程度的相关性。方法 16例正常右利手受试者根据视觉刺激提示右手进行固定频率的三种不同握力运动，同时进行BOLD fMRI 扫描，用spm5计算得到不同握力的脑激活区并比较差异。结果在三种不同握力运动中，对侧主运动区、对侧躯体感觉区、对侧辅助运动区（SMA）和对侧运动前区（PMC）明显激活;同侧激活区较小或者未见激活区；同侧小脑激活区较对侧明显激活。随着握力强度的增高，M1和S1 激活强度、范围都提高；小脑激活程度有所降低。结论正常人手握力运动时脑皮质运动网络被激活，握力刺激强度与M1、S1的激活程度呈正相关。

Objective To study the brain functional activations under several grip force levels. Methods Functional MRI was performed in 16 healthy subjects who alternated between rest and squeezing rubber Oring task at fix frequency （1 Hz）at one of three force levels using right hand. Statistic the brain functional activations under different grip force levels and compare the results using spm5 software. Results For each force level, group analysis results revealed that the contralateral sensorimotor cortex（SMC）,supplementary motor area （SMA） , premotor area （PMC） were activated, and the ipsilaterals were smaller or none. Bilateral cerebellum were activated，and the ipsilateral was stronger. Increased force of squeezing is associated with increased contralateral sensorimotor cortex，but decreased cerebellum. Conclusion Cerebral cortical motor network was extensively activated during grip force movement in normal subjects. Motor cortex neurons show increased activity with increased force of movement.

参考文献：

［1］Jancke L , Peters M , Himmelbach M , et al fMRI study of bimanual coordination . Neuropsycholigia , 2000 ,38 （2） :164-174.
［2］Jancke L , Specht K, Mirzazade S , et al. A parametric analysis of t he ‘rate effect’ in t he sensorimotor cortex: a functional magnetic resonance imaging analysis in human subjects. Neurosci Lett,1998 ,252 （1） :37-40.
［3］Riecker A , Wildgruber D , Mat hiak K, et al. Parametric analysis of ratedependent hemodynamic response functions of cortical and subcortical brain structures during auditorily cued finger tapping: An fMRI study. NeuroImage , 2003 ,18 （3） :7312-7391.
［4］Pope P, Wing AM, Praamst RP, et al. Force related activationsin rhythmic sequence production1 NeuroImage, 2005, 27 （4） :9092-9181.
［5］Crelier GR , Golay X , Alkad WH , et al. Activation in Multiple Cortical Regions in a Visually Cued Grip Force Task : An Eventrelated fMRI Study. NeuroImage , 2000 ,11 （5） :875.
［6］Mueller WM , Yetkin FZ. Functional magnetic resonance imaging of the somatosensory cortex ［J］. NeurosergClin North Am,1997 ,8（3） :373-381.
［7］Kasess CH，Christian Windischberger，Ross Cunnington,et al.The suppressive influence of SMA on M1 in motor imagery revealed by fMRI and dynamic causal modeling NeuroImage,2008：828-837.
［8］Singh LN , Higano S , Takahashi S , et al.Comparison of ipsilateral activation between right and left handers:a fMRI study［J ］ . Neuro Report, 1998, 9（8）: 1861-1866.
［9］朱文珍，漆剑频，王承缘，等.实时功能磁共振成像对运动皮层的定位. 放射学实践，2002，17（1）：59-61.
［10］Hesse MD , Thie CM , Stepha KE , et al. The left parietal cortex and motor intention: An eventrelated functional magnetic resonance imaging study. Neuroscience, 2006,（4）:1209-1221.
［11］Jancke L, Peters M ,Schlaug G,et al. Differential magnetic resonance signal change in human sensorimotor cortex to finger movements of different rate of the dominant and subdominant hand ［J］. Congitive Brain Research, 1998,（4）:279-284.

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