Bone cells include osteoblasts, osteoclasts, osteocytes and bone lining cells. In vivo physiological conditions, the most important mechanical stimulation that bone cells underwent is fluid shear stress. In recent years, research on effects of fluid shear stress on bone cells has made great progress. Current experiments are focusing on the changes in signal molecules, intracellular calcium, gap junction and cell cytoskeleton. Also fluid shear stress could cause some changes in the interaction of bone cells. This paper reviews the progress of the studies in this field.