The development of modification polylactic acid with polysaccharide is reviewed, such as, dextran, starch, chitosan, cyclodextrin, hyaluronic acid and cellulose. The hydrophilicity of modified Polylactic acid with polysaccharide could be improved effectively. The modified polylactides,whose contact angle with water and interfacial energy with tissues、cells and biomacromolecules were reduced, have good biocompatibility. Hydrophilic Polylactides with Polysaccharide function are used for medical device ,delayed release system and tissue engineering.