Objective To investigate the effect of 2D analysis window and amplitude modulation correction (AMC) on the performance of weighted phase separation (WPS) algorithm. Methods Firstly we modified the AMC and WPS to 2D window form. Then we simulated an uniformly elasticity tissue model and applied 0.1%, 1% and 4% strains to the model. After that we produced various elastograms when using 1D and 2D analysis windows respectively also using AMC or not, and computed the signal to noise ratio (SNRe). Finally we conducted phantom experiment by using 2D window and compared the images qualities with AMC and without AMC. Results The simulation results showed that both using 2D analysis window and using AMC could improve elastogram SNRe, and the latter improvement was more prominent. The phantom experiments also confirmed that strain images were smoother and less artifact noise by using 2D analysis window and AMC, the corresponding strain image SNRe also had been improved. Conclusion 2D analysis and AMC could improve the performance of WPS algorithm and improve elasogram quality.