The pulse wave signals contain plenty of information which conveys the health status of human body. To acquire and analyze the pulse signals, we developed a kind of pressure sensors, by adopting soft-touch metal dome craftsmanship. The oscillator amplifier 555 and V-f conversion circuit were utilized to transform the pressure signals into electric signals Then the system effectively acquired the pulse signals by following filter circuit, band stop circuit, amplifier circuit and the method of interference. Experiments of performance test to pressure sensor and oscilloscope proved that the test system based on thin film pressure sensor had reliable performance and could be used to study the pulse wave by the collected pulse signals shown on the computer through the serial communication expansion module of the oscilloscope or the data acquisition card of LABVIEW.