设为首页 |  加入收藏
首页首页 期刊简介 消息通知 编委会 电子期刊 投稿须知 广告合作 联系我们
生物可降解材料在医学领域的应用

Application of Biodegradable Materials in Medical Specialty

作者: 周建    杨秀滨 
单位:北京协和医学院,中国医学科学院,阜外心血管病医院(北京100037)
关键词: 生物可降解材料;天然可降解类材料;人工合成可降解材料;临床应用 
分类号:
出版年·卷·期(页码):2011·30·3(326-330)
摘要:

生物可降解材料包括天然可降解材料和人工合成可降解材料,由它们制成的产品应用于人体后可逐渐被降解吸收。本文综述了部分已应用于临床的生物可降解材料的特性、种类和应用现状,其中包括甲壳素、胶原蛋白、细菌纤维素、聚羟基丁酸酯、聚乳酸、聚乙醇酸、聚对二氧环己酮和聚丁二酸丁二醇酯及磷酸钙,并对相关的需要解决的问题进行了讨论。总之生物可降解材料所具有的理化结构和降解特性决定其运用于医用产品将会发挥有益的治疗作用,尽管目前只在有限范围应用,在实际应用时也存在一些问题,但生物可降解材料将会有广阔的应用前景。

Biodegradable materials comprises natural biodegradable materials and artificially synthesized biodegradable materials.The products made by biodegradable materials can be completely absorbed after being applied on humans.This review illustrates the character,types,application status  of the biodegradable materials that have been clinically used such as chitin,collagen,bacterial cellulose,polyhydroxybutyrate,polylactic acid,polyglycolic acid,PPDO,PBS and β-TCP.We also discussed the problems occurring when they are in use.The medical products made by biodegradable materials do have beneficial therapeutic effects on human body for its physical and chemical characteristics.Though the biodegradable materials still have some problems and is limited in use,they will have the broad application prospect in the future.

参考文献:

[1]Hench L,Polak J.Third generation biomaterials[J].Science,2002,295: 1014-1017.
[2]Lyu SP,Untereker D.Degradability of polymers for implantable biomedical devices[J].Int J Mol Sci,2009,10: 4033-4065.
[3]胡平.组织工程用外科植入物-高分子材料的加工、改性及应用[J].中国医疗器械信息,2006,12(7): 13-21,35.
[4]Gu R,Sun W,Zhou H,et al.The performance of a fly-larva shell-derived chitosan sponge as an absorbable surgical hemostatic agent[J].Biomaterials,2010,31(6): 1270-1277.
[5]Muzzarelli R A.Chitins and chitosans as immunoadjuvants and non-allergenic drug carriers[J].Mar Drugs,2010,8(2): 292-312.
[6]Dai T,Tegos GP,Burkatovskaya M,et al.Chitosan acetate bandage as a topical antimicrobial dressing for infected burns[J].Antimicrob Agents Chemother,2009,53(2): 393-400.
[7]Gelse K,Aigner T.Collagens-structure,function and biosynthesis[J].Adv Drug Deliv Rev,2003,55(12): 1531-1546.
[8]Burke JF,Yannas IV,Quinby WC,Successful use of a physiologically acceptable artificial skin in the treatment of extensive burn injury[J].Ann Surg,1981,194(4): 413-428.
[9]Enoch S,Gery J E,Harding KG.ABC of wound healing: recent advances and emerging treatments[J].BMJ,2006,332(22): 962-965.
[10]Gabay M.Absorbable hemostatic agents[J].Am J Health Syst Pharm,2006,63(13): 1244-1253.
[11]Yamanaka S,Watanabe K,Kitamura N,et al.The structure and mechanical properties of sheets prepared from bacterial cellulose[J].J Mater Sci,1989,24: 3141-3145.
[12]Czaja W,Krystynowicz A,Bielecki S,et al.Microbial cellulose—the natural power to heal wounds[J].Biomaterials,2006,27: 145-151.
[13]Anderson AJ,Dawes EA.Occurrence,metabolism,metabolic role and industrial uses of bacterial polyhydroxyalkanoates[J].Microbiol Rev,1990,54(4): 450-472.
[14]Kulkarni R,Panic K C,Neuamn C,et al.Polylactic acid for surgical implants[J].Arch Surg,1966,93(5): 839-843.
[15]Yeo Y,Kohane DS.Polymers in the prevention of peritoneal adhesions[J].Eur J Pharm Biopharm,2008,68(1): 57-66.
[16]Enislidis G,Yerit K,Wittwer G,et al.Self-reinforced biodegradable plates and screws for fixation of zygomatic fractures[J].J Craniomaxillofac Surg,2005,33(2): 95-102.
[17]Tamai H,Igaki K,Kyo E,et al.Initial and 6-month results of biodegradable poly-l-lactic acid coronary stents in humans[J].Circulation,2000,102: 399-404.
[18]Greenberg JA,Clark RM.Advances in suture material for obstetric and gynecologic surgery[J].Rev Obstet Gynecol,2009,2(3): 146-158.
[19]Imola MJ,Hamlar DD,Shao W,et al.Resorbable plate fixation in pediatric craniofacial surgery: long-term outcome.Arch Facial Plast Surg,2001,3(2): 79-90.
[20]徐向奎,冯亚凯,薛燕.对二氧环己酮及其聚合物的研究进展[J].化学工业与工程,2008,25(3): 259-263.
[21]华琨,杨秀滨.合成类可降解材料在心血管外科的应用[J].实用临床医药杂志,2009,13(2):86-89.
[22]Giannoudis PV,Dinopoulos H,Tsiridis E.Bone substitutes: an update[J].Injury,2005,36Suppl 3: S20-27.
[23]Bosman O,Hirvensalo E,Makinen J,et al.Foreign-body reactions to fraction fixation implants of biodegradable synthetic polymer[J].J Bone Joint Surg Br,1990,72-B(4): 592-596.
[24]Figueras J,Llado L,Miro M,et al.Application of fibrin glue sealant after hepatectomy does not seem justified-results of a randomized study in 300 patients[J].Ann Surg,2007,245(4): 536-542.

服务与反馈:
文章下载】【加入收藏
提示:您还未登录,请登录!点此登录
 
友情链接  
地址:北京安定门外安贞医院内北京生物医学工程编辑部
电话:010-64456508  传真:010-64456661
电子邮箱:llbl910219@126.com