北京生物医学工程

生物医学计算器软件的研制

Development of a Biomedical Calculator Software

作者：杨连君司晓辉刘艳琳吕晶张雪

单位：煤炭总医院病理科（北京100028）

关键词：生物医学计算器；软件；统计

分类号：

出版年·卷·期（页码）：2011·30·4（409-411）

摘要：

目的为简化生物医学统计过程和辅助实验研究，开发一个方便实用的计算机程序软件。方法设计并编写了生物医学计算器(biomedical calculator,BioMedCalc)软件，实现包括计算均数和标准差、卡方检验、两组样本均数t检验、直线相关与回归、Spearman检验等5个数据统计功能；该BioMedCalc计算软件具有计算PCR实验试剂配比的PCR计算器，计算寡核苷酸序列长度、各碱基数、（G+C）含量和配制常用终浓度所需蒸馏水量的寡核苷酸计算器，计算试剂量的溶液配制计算器，以及进行离心机转数和相对离心力之间换算，进行货币比值换算的外汇兑换计算器，用于精确计时、闹钟和语音报时的数字时钟记时器等6个实验辅助功能。结果经验算，BioMedCalc的5个数据统计功能与SPSS软件和手工方法计算的结果均完全一致，并且更为简便；6个实验辅助功能也均与手工验算的结果完全一致。结论 BioMedCalc是简便实用的生物医学统计和实验辅助软件，尤其适用于病理研究。

Purpose To predigest the process of biomedical statistics and assist in experimental study, we developed a simple and convenient computer-programmed software. Methods The software for biological and medical calculator (BioMedCalc) is designed and programmed. BioMedCalc included 5 data statistic functions, which were average and standard difference calculations, Chi-square (χ2) and two-sample t tests, Linear correlation and regression and spearman’s rank correlation. The BioMedCalc also included 6 experiment-assistant functions, PCR calculator for calculating the regent scale in PCR experiments, Oligo calculator for counting the sequence length, number of base-pair, content of GC and the quantity of distilled water to make normal final concentration, the centrifugation calculator used for conversing the rotation speed to relative centrifugal force, the solution matcher of calculating the quantity of regent, the foreign exchanger for the exchange between different moneys, and even the clock and timer used for exactly timing and alarming with sound report. Results The result of checking calculation indicated that all the statistic functions were identical to SPSS software and manual calculation, and more simple and convenient. All the experiment-assistant functions were also identical to manual calculation. Conclusions Software BioMedCalc is an easy and convenient biomedical statistic and experiment-assistant software, especially suitable for pathologic studies.

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