Objective To evaluate the clinical value of tissue Doppler in minimal-invasive surgical device closure of atrial septal defects, the tissue Doppler was utilized for measuring the movement of right ventricular wall. Methods Echocardiography tests were performed before operation and 3 to 5 days after the operation while 65 patients with secundum atrial septal defects underwent minimal-invasive surgical device closure. The tissue Doppler velocity spectra were detected to measure the movement of tricuspid annulus and middle part of right ventricle. Systolic peak velocity(s′), early diastolic peak velocity (e′) and late diastolic peak velocity (a′) of tricuspid annulus and middle part of right ventricle were analyzed, and M mode tissue Doppler of interventricular septum and left ventricular posterior wall were analyzed as well. Results Compared with the preoperation values, the after operation values of the systolic peak velocity(s′) and late diastolic peak velocity (a′) of tricuspid annulus decreased significantly (P<0.01),and early diastolic peak velocity (e′) of right ventricle also decreased significantly (P<0.01). And the abnormal motion of interventricular septum was improved after the closure of atrial septal defects. Conclusions Tissue Doppler is supposed as a tool in evaluating the changes of right ventricular motion in minimal-invasive surgical device closure of secundum atrial septal defects.