北京生物医学工程

Fe-Fe3O4核壳结构纳米材料的制备与表征

Synthesis and characterization of Fe-Fe3O4 core-shell nanoparticles

作者：史慧慧段磊杨再新钟伟吴小玲

单位：南京医科大学基础医学院（南京 210029）

分类号：

出版年·卷·期（页码）：2012·31·2（170-173）

摘要：

目的通过还原-氧化方法使作为前躯体的Fe3O4纳米颗粒具有Fe-Fe3O4核壳结构，以作为磁靶向药物载体。方法在管式炉中以H2还原Fe3O4纳米颗粒后，利用压差作用下进入的少量空气缓慢氧化还原后物质，以制备符合预期要求的Fe-Fe3O4核壳结构纳米粒子，并分析产物的X射线衍射（X-ray diffraction，XRD）、透射电子显微镜（transmission electron microscopy，TEM）和振动样品磁强计（vibrating sample magnetometer，VSM）表征结果。结果通过还原-氧化法制备的Fe-Fe3O4核壳结构纳米粒子，形状近似球形，粒径主要分布在60～100 nm，比饱和磁化强度达108emu/g，比Fe3O4纳米颗粒高30emu/g，且稳定性良好。结论还原-氧化法制备的Fe-Fe3O4核壳结构纳米颗粒比前躯体磁性强，并具有较高的化学稳定性和生物相容性。

Objective Through the procedure of reduction and oxidation，Fe3O4 nanoparticles，as the precursor，were changed into Fe/Fe3O4 core-shell nanoparticles to produce magnetic materials for targeting drug carrier.Methods Fe3O4 nanoparticles were first reduced by H2 in a tube furnace and then the remaining materials were slowly oxidized in a thin air atmosphere caused by the pressure difference inside and outside the tube furnace. The products were analyzed by X-ray diffraction (XRD)，transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) Results The as-synthesized particles were almost spherical，the particle diameter ranged from 60nm to 100 nm.The special saturation magnetization was 108emu/g，30emu/g higher than the precursor.Conclusions The Fe/Fe3O4 core-shell structure shows higher special saturation magnetization than the precursor as well as greater chemical stability and biocompatibility.

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