Objective To investigate selective nerve activation of high frequency biphasic electrical current using the symmetric and asymmetric square wave biphasic pulses. The study aimed to find an optimal waveform stimulus pattern for the selectively stimulating nerve fibers effectively. This study can provide more information for the clinical applications of electrical nerve block. Methods We used the sciatic nerve of live animals as the research object and established neural selective stimulation model. This paper presented biphasic pulse modes respectively with different pulses including symmetric square wave,asymmetric square wave 2∶1,asymmetric square wave 3∶1 stimulus waveform,which can selectively stimulate nerve fibers effectively. Results we obtained the best stimulation waveform,through the comparison of the selective nerve activation consequents in the three electrical stimulation modes. Conclusions The asymmetric square wave 3∶1 stimulation mode is the optimal waveform stimulus pattern.
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