设为首页 |  加入收藏
首页首页 期刊简介 消息通知 编委会 电子期刊 投稿须知 广告合作 联系我们
基于在体动物实验的高频交流电刺激的_________

Selective nerve activation study with high frequency alternating electrical current based on animal experiment

作者:               朱晓瑾  张旭  王辉  任朝晖  刘庆凯  阎立丽  李春婵          
单位:           首都医科大学生物医学工程学院(北京100069)    
关键词:           神经;选择性刺激;双向脉冲;动物实验      
分类号:
出版年·卷·期(页码):2013·32·2(117-121)
摘要:

目的 研究高频双向对称方波对神经的选择性兴奋影响,对实现特定直径范围神经的兴奋具有重要的意义,并为功能神经电刺激的临床应用提供更多信息。方法 以在体动物的坐骨神经为研究对象,建立神经选择性刺激模型。首先使用高频双向对称方波进行实验,通过改变高频双向对称方波后测试脉冲出现的延迟时间或者高频双向对称方波的频率,得出经高频刺激后兴奋神经所需的阈值,从而实现神经的选择性兴奋。然后将对称方波刺激波形变为非对称方波2∶1、非对称方波3∶1后进行重复实验。结果 用高频双向方波实现了神经的选择性兴奋,并对比了在对称方波、非对称方波2∶1、非对称方波3∶1三种不同刺激波形下对神经的选择性兴奋的效果,得出了最佳的刺激模式。结论 三种刺激波形的刺激模式下,选用电荷平衡的非对称方波3∶1实现的神经选择性兴奋最佳。

Objective To investigate selective nerve activation of high frequency biphasic electrical current using the symmetric and asymmetric square wave biphasic pulses. The study aimed to find an optimal waveform stimulus pattern for the selectively stimulating nerve fibers effectively. This study can provide more information for the clinical applications of electrical nerve block. Methods We used the sciatic nerve of live animals as the research object and established neural selective stimulation model. This paper presented biphasic pulse modes respectively with different pulses including symmetric square wave,asymmetric square wave 2∶1,asymmetric square wave 3∶1 stimulus waveform,which can selectively stimulate nerve fibers effectively. Results we obtained the best stimulation waveform,through the comparison of the selective nerve activation consequents in the three electrical stimulation modes. Conclusions The asymmetric square wave 3∶1 stimulation mode is the optimal waveform stimulus pattern.

参考文献:

[1]Blair EA,Erlanger JA. A comparison of the characteristics of axons through their individual electrical responses [J]. Am J Physiol-Legacy Content,1933,106(3):524-564.
[2]Koldewijn EL,Rijkhoff NJ,Van Kerrebroeck E V,et al. Selective sacral root stimulation for bladder control:Acute experiments in an animal model [J]. J Urol,1994,151(6):1674-1679.
[3]Tosato M,Yoshida K,Toft E,et al. Closed-loop control of the heart rate by electrical stimulation of the vagus nerve [J]. Med Biol Eng Comput,2006,44(3):161-169.
[4]Zhou BH,Baratta R,Solomonow M. Manipulation of muscle force with various firing rate and recruitment control strategies [J]. IEEE Trans Biomed Eng,1987,34(2):128-139.
[5]Solomonow M. External control of the neuromuscular system [J]. IEEE Trans Biomed Eng,1984,BME-31(12):752-763.
[6]Solomonow M,Eldred E,Lyman J,et al. Control of muscle contractile force through indirect high-frequency stimulation [J]. Am J Phys Med,1983,62(2):71-82.
[7]Ishigooka M,Hashimoto T,Sasagawa I,et al. Modulation of the urethral pressure by high-frequency block stimulus in dogs [J]. Eur Urol,1994,25(4):334-337.
[8]Baratta R,Ichie M,Hwang SK,et al. Orderly stimulation of skeletal muscle motor units with tripolar nerve cuff electrode [J]. IEEE Trans Biomed Eng,1989,36(8):836-843.
[9]Bossetti CA,Birdno MJ,Grill WM. Analysis of the quasi-static approximation for calculating potentials generated by neural stimulation[J]. J Neural Eng,2008,5(1):44-53.
[10]董谦,张旭,陈国庆,等. 低频电刺激对脊髓损伤后膀胱过度活动抑制的仿真研究[J].北京生物医学工程,2011,30(1):10-14.
Dong Qian,Zhang Xu,Chen Guoqing,et al. Simulation research on inhibition effect of overactive bladder after spinal cord injury using low frequency electrical stimulation[J]. Beijing Biomedical Engineering,2011,30(1):10-14.
[11]沈强,邰常峰,蒋大宗. 用双向脉冲作选择性神经刺激的研究[J]. 中国生物医学工程学报,1999,18(1):36-44.
Shen Qiang,Tai Changfeng,Jiang Dazong. A study on selective stimulation of nerve fibers using biphasic pulses[J]. Chinese Journal of Biomedical Engineering,1999,18(1):36-44.
[12]沈强,刘雪良,蒋大宗,等. 利用双向方波脉冲刺激实现神经纤维选择性兴奋的双电极方法[J]. 中国生物医学工程学报,2001,20(6):533-540.
Shen Qiang,Liu Xueliang,Jiang Dazong,et al. Z. A bipolar electrodes study on selective stimulation of nerve fibers using biphasic pulses [J]. Chinese Journal of Biomedical Engineering,2001,20(6):533-540.
[13]张旭,邰常峰,马斌荣. 用高频双向脉冲电刺激实现有髓神经传导阻断的仿真研究[J]. 北京生物医学工程,2006,25(3):280-284.
Zhang Xu,Tai Changfeng,Ma Binrong. Simulation analysis of myelinated axon block by high frequency biphasic electrical current based on Frankenhaeuser Huxley model[J]. Beijing Biomedical Engineering,2006,25(3):280-284.
[14]Mcneal DR. Analysis of a model for excitation of myelinated nerve [J]. IEEE Trans Biomed Eng,1976,23(4):329-337.

服务与反馈:
文章下载】【加入收藏
提示:您还未登录,请登录!点此登录
 
友情链接  
地址:北京安定门外安贞医院内北京生物医学工程编辑部
电话:010-64456508  传真:010-64456661
电子邮箱:llbl910219@126.com