北京生物医学工程

鼻咽癌容积调强放射治疗剂量验证比较研究

Comparison of dose verification in volumetric modulated arc therapy for nasopharyngeal carcinoma

作者：岳海振贾飞张健吴昊

单位：北京大学肿瘤医院暨北京市肿瘤防治研究所放疗科，恶性肿瘤发病机制及转化研究教育部重点实验室(北京100142)

分类号：

出版年·卷·期（页码）：2013·32·4（375-379）

摘要：

目的比较6MV-X射线均整模式(6X)和非均整模式(6FFF)容积旋转调强治疗(volumetric modulated arc therapy，VMAT)技术在鼻咽癌放射治疗中的剂量验证结果，验证6FFF容积调强计划的临床可行性。方法用PTW公司二维电离室矩阵Array729和OCTAVIUS Octagonal模体对15例患者的6X和6FFF VMAT计划进行剂量验证。结果采用gamma 2D进行分析(按3mm和3%的误差标准)，6X local dose方法通过率为(95±3)%，max dose方法通过率为(96±3)%，6FFF local dose方法通过率为(94±3)%，max dose方法通过率为(95±3)%。结论 PTW Array729可用于6X和6FFF VMAT计划的临床验证，6FFF计划的通过率略低于6X，local dose方式二者之间差异无统计学意义(P>0.05)，max dose方式二者之间差异具有显著的统计学意义(P<0.01)。同一计划的验证结果采用 local dose评判方法通过率低于max dose，具有显著的统计学意义(P<0.001)。

Objective To compare the dose verification between 6X and 6X flattening filter-free(6FFF) in volumetric modulated arc therapy (VMAT) for the treatment of nasopharyngeal carcinoma(NPC)，and verify the clinical feasibility of 6FFF VMAT plan. Methods The two dimensional ionization chamber matrix Array729 and OCTAVIUS Octagonal phantom from PTW Company were used to verify the 6X and 6FFF VMAT plan of 15 patients. Results Gamma 2D analysis criteria was used to evaluate the verification results (standard error as 3mm and 3%)，the pass rate of local dose method for 6X was (95±3) %，while the max dose method was (96±3) %. For 6FFF，local dose method was (94±3) %，and max dose method was (95±3) %. Conclusions PTW Array729 can be used for clinical validation of 6X and 6FFF VMAT plans，the pass rate of 6FFF plan is lower than that of 6X plan，P>0.05 for local dose，and P<0.01 for max dose. The pass rate of local dose method is less than max dose (P<0.001) in the dose verification result for the same plan.

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