北京生物医学工程

基于无线充电技术的胃肠电刺激系统

Gastrointestinal stimulating system based on wireless charging technology

作者：李宝伟姜萍萍颜国正

单位：上海交通大学医学精密工程及智能系统研究所(上海 200240)

分类号：

出版年·卷·期（页码）：2013·32·6（624-631）

摘要：

目的设计一种新型的植入式胃肠道刺激系统，不仅具有刺激功能，还具有肠电和压力检测功能，可用于检测胃肠道刺激的效果，同时增加无线能量供给，以实现刺激器的长期植入。方法系统由体内刺激模块、体外控制模块及无线能量传输模块组成。体外控制模块通过无线射频将控制信号传输到体内刺激模块，体内刺激模块的能量由体外能量发射装置通过电磁耦合进行供给。通过生物反馈控制检测不同刺激参数对胃肠道收缩活动的作用效果，实时调整刺激参数，输出需要的刺激脉冲。以模拟心电信号模拟肠电信号，进行了相关的体外实验。结果在体外实验中，系统可有效检测到2~20次/min的模拟心电信号，并实现实时刺激参数修改输出不同的刺激脉冲。该系统实现了电流检测功能，监测作用部分的胃肠电阻。经皮无线能量在两级线圈轴向距离为22mm时的接收充电稳定功率最大为0.93W，体内锂离子的充电电流为180~240mA。结论系统可检测到最大变化范围的模拟肠电信号。验证电流的作用效应为后续的恒流刺激模式提供参考。该系统的无线充电功能可满足植入式刺激器长期植入的能量需求。

Objective A new type of implantable electrical stimulation system is designed with the stimulating function and the function of intestinal signal and pressure detection in order to detect the result of electrical stimulation. And the function of wireless energy supply is added to insure that the stimulator can be long-time planted. Methods The system consists of internal stimulator, external controller and wireless energy transmitting modules. The control signal is transformed from external controller to internal stimulator through RF. The energy of the internal stimulator is captured from external transmitting devices by using electromagnetic couple technology. We detect gastrointestinal contraction under different stimulating parameters with biofeedback control technology. So we can adjust the stimulating parameters to output stimulating pulse we need. Results This system detects 2 to 20 cpm analogous electrocardiograph signals effectively for adjusting the parameter to produce different stimulating pulse in vitro. Meanwhile, we realize current detecting function and the detection of the gastrointestinal resistor stimulated. The maximum of received stable power in vivo is 0.93 W and the charging current can be 180 mA to 240 mA as the coil distance is 22 mm. Conclusions This system can detect the maximum variation range of simulated intestinal signal. Verification of the current action effects provides a reference for constant current stimulation mode in the future. The wireless charging function meets the energy requirement for the long-term implantation of the stimulator.

参考文献：

［1］AeUen S，Wiesel PH，Gardaz JP，et a1．Electrical stimulation induces propagated colonic contractions in all experimental model［J］.Br J Surg，2009,96(2)：214-220．
［2］Yin J，Chen JDz． Excitatory effects of synchronized intestinal electrical stimulation on small intestinal motility in dogs［J］．Am J Physiol Gastrointest Liver Physiol，2007,293(6)：G1190-G1195．
［3］李路明，郝红伟. 植入式神经刺激器的现状与发展趋势［J］.中国医疗器械杂志, 2009,33(2)：107-111.
［4］Xu J，Chen JD．Intestinal electrical stimulation improves delayed gastric emptying and vomiting induced by duodenal distension in dogs［J］．Neurogastroenterol Motil,2008，20(3)：236-242．
［5］Design of A portable microprocessor-based stimulator for the recreation of impaired gastrointestinal mobility Electronics, Circuits and Systems, 2001［C］. ICECS 2001. The 8th IEEE International Conference on，2001:1187-1190.
［6］Sanmiguel CP，Conklin JL，Cunneen SA，et al．Gastric electrical stimulation with the TANTALUS(R)system in obese type 2 diabetes patients: effect on weight and glycemic control．Journal of Diabetes Science and Technology, 2009，3(4): 964-970．
［7］Alonso L M,Minor A,Escamilla C.Design of a Transcutaneous Electrical Stimulator to Avoid the Postoperative Intestinal Effects Electrical and Electronics Engineering, 2007［C］. ICEEE 2007. 4th International Conference on 2007:90-93.
［8］陈军, 余跃. 胃肠电刺激和胃肠动力紊乱研究进展［J］. 胃肠病学和肝病学杂志, 2010, 19(4):382-384.
Chen Jun, Yu Yue.Advances in gastrointestinal electrical stimulation and gastrointestinal dysmotility［J］. Chinese Journal of Gastroenterology and Hepatology, 2010, 19(4):382-384.
［9］顾晓斌, 黄晓群, 王成喜. 小儿腹痛的胃肠电图诊断价值［J］. 临床合理用药, 2011, 4(21):82-83.
［10］连至诚, 王建华,劳绍贤,等. 体表结肠电检测分析方法的基础及应用研究［J］. 广州中医学院学报, 1990，(3):170-174.
［11］许茜茜，刘华，颜国正. 植入式人工肛门括约肌系统的实现及动物实验［J］.中国组织工程研究, 2012,16(13):2336-2341.
Xu Qianqian, Liu Hua, Yan Guozheng. Implementation and animal experiment of an implantable artificial anal sphincter system［J］. Journal of Clinical Rehabilitative Tissue Engineering Research, 2012, 16(13):2336-2341.

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