北京生物医学工程

基于三维斑点追踪成像技术的心肌形变生物力学特征分析——左心室心肌纵向应变

Analysis on biomechanical characteristics of myocardial morphological changes based on threedimensional echocardiography images——myocardial longitudinal strain analysis

作者：李宜嘉孙妍杨娅马宁张纯李嵘娟孙琪玮薛静莉杨娇李文铮

单位：                                 首都医科大学附属北京安贞医院-北京市心肺血管疾病研究所（北京100029）            

关键词：生物力学; 斑点追踪技术; 三维纵向应变; 心功能

分类号：

出版年·卷·期（页码）：2014·33·6（551-557）

摘要：

目的应用三维斑点追踪技术分析冠脉造影正常者心肌纵向应变，探讨该方法可行性的同时了解心肌的形变力学特征。方法三维斑点追踪技术（three dimensional speckled tracking image, 3DT）是基于实时三维超声心动图技术，对全容积实时三维数据进行自动的室壁运动追踪和定量分析的一种新技术。入选冠状动脉造影正常的患者24例，常规超声心动图检查，计算测量左心室内径、容积及功能，应用3DT技术测量左室心肌前间隔、后间隔、前壁、侧壁、下壁、后壁的基底段、中间段及心尖段共18个节段收缩期峰值应变。结果冠脉造影正常者左室整体运动协调一致，纵向应变为负，收缩期整体峰值应变为-14.27%±4.29%。心尖段峰值应变绝对值最大，基底段最小。心尖段与基底段、中间段各室壁节段纵向峰值应变差异有统计学意义(P<0.01)，基底段与中间段比较，差异无统计学意义(p>0.05)。结论 3DT可通过纵向应变评估冠脉造影正常者左心室心肌形变生物力学特征。

Objective To evaluate the biomechanical characteristics of myocardial morphological changes by using three-dimensional speckle tracking image(3DT) in patients without coronary lesions detected by angiography. Methods Twenty-four patients, without significant coronary lesions detected by angiography, were involved in the echocardiography examination and longitudinal strain analysis by using the 3DT. Results Patients without coronary lesions detected by angiography had the concerted motion of left ventricular. The longitudinal strain was negative, and the peak systolic longitudinal strain was -14.27% ± 4.29%. The maximum absolute value of peak longitudinal strain was at the apical segment, while the minimum one was at basal segment. The differences of peak longitudinal strain between apical segment and middle segment or basal segment were significant (P<0.01), yet="" the="" difference="" between="" middle="" segment="" and="" basal="" was="" not="" significant="" p="">0.05). Conclusions Evaluation of the left ventricular biomechanical characteristics of myocardial morphological changes by 3DT in patients without significant coronary lesions detected by angiography was a convenient and fast method.

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