北京生物医学工程

基于形态学重构的宫腔镜下子宫内膜腺体开口标记算法

Marking algorithm of endometrial glandular openings based on morphological reconstruction under hysteroscopy

作者：杨淼黄晓武闵乐泉姚红串

单位：                                 首都医科大学生物医学工程学院（北京100069）            

关键词：宫腔镜;子宫内膜腺体开口;形态学重构;多尺度高斯滤波器

分类号：

出版年·卷·期（页码）：2015·34·5（468-471）

摘要：

目的在宫腔镜下为胚胎种植窗口期的子宫容受性提供一个量化的评价方法，提

出一个宫腔镜下的子宫内膜腺体开口标记算法。方法采用数学形态学重构算法

提取可能的腺体开口区域，利用多尺度的高斯滤波增强腺体区域去除噪声，最

后使用数学形态学的区域最大值标记腺体开口。结果该标记算法的标记结果与

专家标记结果进行比对，灵敏度为84.72%±8.00%，Dice相似度系数达83.80%±

4.56%。结论经仿真和真实数据验证，提出的子宫内膜腺体开口标记算法是有

效的。

Objective To provide a quantitative evaluation method of the window

of uterine receptivity for implantation, a marking algorithm of

endometrial glandular openings under hysteroscopy was proposed.

Methods Candidate areas of glandular openings were detected by

morphological reconstruction algorithm and enhanced by multi-scale

Gaussian filter, while noises were suppressed. The glandular openings

were finally marked based on the regional maximum value. Results The

result of the proposed algorithm was compared with the result of the

experts. The sensitivity of the proposed algorithm was 84.72% ±

8.00%, Dice similarity coefficient reached 83.80% ± 4.56%.

Conclusions Simulation and experiment results indicated that the

proposed algorithm could effectively mark the endometrial glandular

openings under hysteroscopy.

参考文献：

［1］金丽萍, 王蕊, 梁竹巍, 等. 278 例不孕不育患者宫腔镜检查结果分析［

J］. 中国妇幼保健, 2008, 23(29): 4155-4157.

Jin Liping, Wang Rui, Liang Zhuwei, et al. Analysis of the results of

278 cases of infertility patients with infertility by hysteroscopy ［

J］.Maternal and Child Health Care of China, 2008, 23(29): 4155-4157.

［2］Garuti G, Sambruni I, Colonnelli M, et al. Accuracy of

hysteroscopy in predicting histopathology of endometrium in 1500

women［J］. The Journal of the American Association of Gynecologic

Laparoscopists, 2001, 8(2): 207-213.

［3］夏恩兰，李自新. 妇科内镜学［M］. 北京: 人民卫生出版社，2001.

［4］Inafuku K. Hysteroscopy in midluteal phase of human endometrium

evaluation of functional aspect of the endometrium］［J］. Nihon

Sanka Fujinka Gakkai zasshi, 1992, 44(1): 79-83.

［5］Masamoto H, Nakama K, Kanazawa K. Hysteroscopic appearance of

the mid-secretory endometrium: relationship to early phase pregnancy

outcome after implantation［J］. Human Reproduction, 2000, 15(10):

2112-2118.

［6］冯苗, 李素春, 潘弹, 等. 着床窗期宫腔镜下子宫内膜形态与性激素及其

受体表达的研究［J］. 实用妇产科杂志, 2009 (5): 285-288.

Feng Miao, Li Suchun, Pan Tan, et al. Study on the hysteroscopic

endometrial appearances and the expression of sex-hormone receptor at

the implantation window, ［J］.Journal of Practical Obstetrics and

Gynecology, 2009 (5): 285-288.

［7］Gonzales. 数字图像处理［M］. 阮秋琦,等译. 北京：电子工业出版社，

2011.

［8］Vincent L. Morphological grayscale reconstruction in image

analysis: applications and efficient algorithms［J］. Image

Processing, IEEE Transactions on, 1993, 2(2): 176-201.

［9］Chaudhuri S, Chatterjee S, Katz N, et al. Detection of blood

vessels in retinal images using two-dimensional matched filters［J］.

IEEE Transactions on Medical Imaging, 1989, 8(3): 263-269.

［10］Al-Rawi M, Qutaishat M, Arrar M. An improved matched filter for

blood vessel detection of digital retinal images［J］. Computers in

Biology and Medicine, 2007, 37(2): 262-267.

［11］Zhang B, Zhang L, Zhang L, et al. Retinal vessel extraction by

matched filter with first-order derivative of Gaussian［J］.

Computers in Biology and Medicine, 2010, 40(4): 438-445.

［12］Veta M, van Diest PJ, Willems SM, et al. Assessment of

algorithms for mitosis detection in breast cancer histopathology

images［J］. Medical Image Analysis, 2015, 20(1): 237-248.

服务与反馈：

【文章下载】【加入收藏】

提示：您还未登录，请登录！点此登录