北京生物医学工程

基于ERP和稳态诱发电位的听觉和触觉整合研究

An EEG study of auditory-tactile integration based on event-related potential and steady-state evoked potential

作者：吴天序王小勤

单位：清华大学医学院生物医学工程系 (北京100084)

分类号：R318.04

出版年·卷·期（页码）：2016·35·4（347-353）

摘要：

目的通过记录与分析单一听觉、单一触觉和混合听触觉条件下的头皮脑电信号，探究一种研究大脑听觉和触觉整合现象的分析方法，为研究听觉和触觉整合的神经机制提供基础。方法首先构建听觉和触觉双模态刺激的头皮脑电记录系统，通过采集13例正常受试者在单一模态和混合模态条件下的头皮脑电信号，分别比较不同条件下听觉和触觉事件相关动作电位(event-related potential, ERP)与稳态诱发电位(steady-state evoked potential, SSEP)的差异。结果听觉和触觉整合的ERP信号峰值比单一听觉和单一触觉条件下的幅值更强，脑电响应的潜伏期显著提前，并且混合模态下的稳态诱发电位的能量显著高于单一模态。结论事件相关动作电位信号峰值的潜伏期与幅值以及稳态响应的能量可作为衡量听觉和触觉整合的参数指标，对听觉和触觉整合的研究具有参考意义。

Objective To propose a method to study auditory-tactile integration of human brain based on the brain activity of uni-modal auditory, uni-modal tactle and bi-modal (auditory and tactile) conditions recoded by electroencephalography, which is helpful for investigating the neural mechanisms of auditory and tactile integration. Methods We constructed a custom multi-sensory EEG recording system to study auditory-tactile integration. Using this system, we recorded EEG signals from 13 normal subjects under uni-modal auditory, uni-modal tactile and bi-modal conditions and compared their differences in event-related potential (ERP) and steady-state evoked potential (SSEP). Results The amplitude of ERP peak was enhanced and the latency was shortened in the bi-modal condition than uni-modal conditions. In addition, the energy of SSEP was significantly enhanced in the bi-modal condition than uni-modal conditions. Conclusions The amplitude and latency of ERP peak and the energy of SSEP can be used as parameters to analyze auditory-tactile integration.

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